Ontology highlight
ABSTRACT:
SUBMITTER: Sciarretta S
PROVIDER: S-EPMC4417361 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Cell reports 20150402 1
The mTOR and Hippo pathways have recently emerged as the major signaling transduction cascades regulating organ size and cellular homeostasis. However, direct crosstalk between two pathways is yet to be determined. Here, we demonstrate that mTORC2 is a direct negative regulator of the MST1 kinase, a key component of the Hippo pathway. mTORC2 phosphorylates MST1 at serine 438 in the SARAH domain, thereby reducing its homodimerization and activity. We found that Rictor/mTORC2 preserves cardiac str ...[more]