Ontology highlight
ABSTRACT:
SUBMITTER: Bai HW
PROVIDER: S-EPMC4417470 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Pharmacogenetics and genomics 20090101 1
Human catechol-O-methyltransferase (COMT; EC 2.1.1.6) catalyzes the transfer of the methyl group to a variety of endogenous and exogenous catechol substrates using S-adenosyl-L-methionine as the methyl donor. This enzymatic O-methylation plays an important role in the inactivation of biologically active and toxic catechols. A number of studies in recent years have sought to characterize the polymorphism of human COMTs and also to determine the catalytic activity of polymorphic enzymes. We report ...[more]