Ontology highlight
ABSTRACT:
SUBMITTER: de Araujo-Souza PS
PROVIDER: S-EPMC4418004 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
de Araújo-Souza Patrícia S PS Hanschke Steffi C H SC Viola João P B JP
Journal of immunology research 20150420
Interferon- (IFN-) γ is an essential cytokine for immunity against intracellular pathogens and cancer. IFN-γ expression by CD4 T lymphocytes is observed only after T helper (Th) 1 differentiation and there are several studies about the molecular mechanisms that control Ifng expression in these cells. However, naïve CD8 T lymphocytes do not produce large amounts of IFN-γ, but after TCR stimulation there is a progressive acquisition of IFN-γ expression during differentiation into cytotoxic T lymph ...[more]