Dataset Information

Value of Computerized 3D Shape Analysis in Differentiating Encapsulated from Invasive Thymomas.

ABSTRACT:

Objectives

To retrospectively investigate the added value of quantitative 3D shape analysis in differentiating encapsulated from invasive thymomas.

Materials and methods

From February 2002 to October 2013, 53 patients (25 men and 28 women; mean age, 53.94 ± 13.13 years) with 53 pathologically-confirmed thymomas underwent preoperative chest CT scans (slice thicknesses ? 2.5 mm). Twenty-three tumors were encapsulated thymomas and 30 were invasive thymomas. Their clinical and CT characteristics were evaluated. In addition, each thymoma was manually-segmented from surrounding structures, and their 3D shape features were assessed using an in-house developed software program. To evaluate the added value of 3D shape features in differentiating encapsulated from invasive thymomas, logistic regression analysis and receiver-operating characteristics curve (ROC) analysis were performed.

Results

Significant differences were observed between encapsulated and invasive thymomas, in terms of cystic changes (p=0.004), sphericity (p=0.016), and discrete compactness (p=0.001). Subsequent binary logistic regression analysis revealed that absence of cystic change (adjusted odds ratio (OR) = 6.636; p=0.015) and higher discrete compactness (OR = 77.775; p=0.012) were significant differentiators of encapsulated from invasive thymomas. ROC analyses revealed that the addition of 3D shape analysis to clinical and CT features (AUC, 0.955; 95% CI, 0.935-0.975) provided significantly higher performance in differentiating encapsulated from invasive thymomas than clinical and CT features (AUC, 0.666; 95% CI, 0.626-0.707) (p<0.001).

Conclusion

Addition of 3D shape analysis, particularly discrete compactness, can improve differentiation of encapsulated thymomas from invasive thymomas.

SUBMITTER: Lee JH

PROVIDER: S-EPMC4418613 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Value of Computerized 3D Shape Analysis in Differentiating Encapsulated from Invasive Thymomas.

Lee Jong Hyuk JH Park Chang Min CM Park Sang Joon SJ Bae Jae Seok JS Lee Sang Min SM Goo Jin Mo JM

PloS one 20150504 5

<h4>Objectives</h4>To retrospectively investigate the added value of quantitative 3D shape analysis in differentiating encapsulated from invasive thymomas.<h4>Materials and methods</h4>From February 2002 to October 2013, 53 patients (25 men and 28 women; mean age, 53.94 ± 13.13 years) with 53 pathologically-confirmed thymomas underwent preoperative chest CT scans (slice thicknesses ≤ 2.5 mm). Twenty-three tumors were encapsulated thymomas and 30 were invasive thymomas. Their clinical and CT char ...[more]

PMID: 25938505

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Dataset Information

Value of Computerized 3D Shape Analysis in Differentiating Encapsulated from Invasive Thymomas.

Objectives

Materials and methods

Results

Conclusion

Publications

Value of Computerized 3D Shape Analysis in Differentiating Encapsulated from Invasive Thymomas.

Similar Datasets

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