Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.
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ABSTRACT:
SUBMITTER: Kam KR
PROVIDER: S-EPMC4418930 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.
Kam Kimberly R KR Walsh Laura A LA Bock Suzanne M SM Koval Michael M Fischer Kathleen E KE Ross Russell F RF Desai Tejal A TA
Nano letters 20121224 1
Herein, we demonstrate that nanotopographical cues can be utilized to enable biologics >66 kDa to be transported across epithelial monolayers. When placed in contact with epithelial monolayers, nanostructured thin films loosen the epithelial barrier and allow for significantly increased transport of FITC-albumin, FITC-IgG, and a model therapeutic, etanercept. Our work highlights the potential to use drug delivery systems which incorporate nanotopography to increase the transport of biologics acr ...[more]
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