Ontology highlight
ABSTRACT:
SUBMITTER: Peeters M
PROVIDER: S-EPMC4419154 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Peeters Marc M Karthaus Meinolf M Rivera Fernando F Terwey Jan-Henrik JH Douillard Jean-Yves JY
Drugs 20150501 7
Tumour biomarker status is being used more and more frequently to guide treatment decisions in patients with metastatic colorectal cancer (mCRC). Continued cycles of hypothesis generation and biomarker testing in retrospective, prospective-retrospective and prospective analyses from studies of the epidermal growth factor (EGFR)-targeted monoclonal antibodies (mAbs), panitumumab and cetuximab, have resulted in improved patient selection in mCRC. Initial data suggested EGFR-targeted mAb treatment ...[more]