Ontology highlight
ABSTRACT:
SUBMITTER: Moreau A
PROVIDER: S-EPMC4420248 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Moreau Aurélie A Vandamme Céline C Segovia Mercedes M Devaux Marie M Guilbaud Mickaël M Tilly Gaëlle G Jaulin Nicolas N Le Duff Johanne J Cherel Yan Y Deschamps Jack-Yves JY Anegon Ignacio I Moullier Philippe P Cuturi Maria Cristina MC Adjali Oumeya O
Molecular therapy. Methods & clinical development 20140723
Preventing untoward immune responses against a specific antigen is a major challenge in different clinical settings such as gene therapy, transplantation, or autoimmunity. Following intramuscular delivery of recombinant adeno-associated virus (rAAV)-derived vectors, transgene rejection can be a roadblock to successful clinical translation. Specific immunomodulation strategies potentially leading to sustained transgene expression while minimizing pharmacological immunosuppression are desirable. T ...[more]