Ontology highlight
ABSTRACT:
SUBMITTER: Cozzi R
PROVIDER: S-EPMC4420484 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cozzi Roberta R Malito Enrico E Lazzarin Maddalena M Nuccitelli Annalisa A Castagnetti Andrea A Bottomley Matthew J MJ Margarit Immaculada I Maione Domenico D Rinaudo C Daniela CD
PloS one 20150505 5
Group B Streptococcus (GBS) is a major cause of invasive disease in infants. Like other Gram-positive bacteria, GBS uses a sortase C-catalyzed transpeptidation mechanism to generate cell surface pili from backbone and ancillary pilin precursor substrates. The three pilus types identified in GBS contain structural subunits that are highly immunogenic and are promising candidates for the development of a broadly-protective vaccine. Here we report the X-ray crystal structure of the backbone protein ...[more]