Structural insight into effector proteins of Gram-negative bacterial pathogens that modulate the phosphoproteome of their host.

ABSTRACT: Invading pathogens manipulate cellular process of the host cell to establish a safe replicative niche. To this end they secrete a spectrum of proteins called effectors that modify cellular environment through a variety of mechanisms. One of the most important mechanisms is the manipulation of cellular signaling through modifications of the cellular phosphoproteome. Phosphorylation/dephosphorylation plays a pivotal role in eukaryotic cell signaling, with ∼ 500 different kinases and ∼ 130 phosphatases in the human genome. Pathogens affect the phosphoproteome either directly through the action of bacterial effectors, and/or indirectly through downstream effects of host proteins modified by the effectors. Here we review the current knowledge of the structure, catalytic mechanism and function o

SUBMITTER: Grishin AM 

PROVIDER: S-EPMC4420512 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature