Ontology highlight
ABSTRACT:
SUBMITTER: Eisenmesser EZ
PROVIDER: S-EPMC4420516 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20150128 5
Crimean-Congo Hemorrhagic fever virus (CCHFV) is one of several lethal viruses that encodes for a viral ovarian tumor domain (vOTU), which serves to cleave and remove ubiquitin (Ub) and interferon stimulated gene product 15 (ISG15) from numerous proteins involved in cellular signaling. Such manipulation of the host cell machinery serves to downregulate the host response and, therefore, complete characterization of these proteases is important. While several structures of the CCHFV vOTU protease ...[more]