Ontology highlight
ABSTRACT:
SUBMITTER: Nolen TL
PROVIDER: S-EPMC4420691 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Statistics in medicine 20150309 12
Preclinical evaluation of candidate human immunodeficiency virus (HIV) vaccines entails challenge studies whereby non-human primates such as macaques are vaccinated with either an active or control vaccine and then challenged (exposed) with a simian-version of HIV. Repeated low-dose challenge (RLC) studies in which each macaque is challenged multiple times (either until infection or some maximum number of challenges is reached) are becoming more common in an effort to mimic natural exposure to H ...[more]