Ontology highlight
ABSTRACT:
SUBMITTER: Golla SS
PROVIDER: S-EPMC4420859 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Golla Sandeep S V SS Boellaard Ronald R Oikonen Vesa V Hoffmann Anja A van Berckel Bart N M BN Windhorst Albert D AD Virta Jere J Haaparanta-Solin Merja M Luoto Pauliina P Savisto Nina N Solin Olof O Valencia Ray R Thiele Andrea A Eriksson Jonas J Schuit Robert C RC Lammertsma Adriaan A AA Rinne Juha O JO
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150204 5
Fluorine-18 labelled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide ([(18)F]DPA-714) binds to the 18-kDa translocator protein (TSPO) with high affinity. The aim of this initial methodological study was to develop a plasma input tracer kinetic model for quantification of [(18)F]DPA-714 binding in healthy subjects and Alzheimer's disease (AD) patients, and to provide a preliminary assessment whether there is a disease-related signal. Ten AD patient ...[more]