Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke.
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ABSTRACT:
SUBMITTER: Darsalia V
PROVIDER: S-EPMC4420864 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke.
Darsalia Vladimer V Larsson Martin M Nathanson David D Klein Thomas T Nyström Thomas T Patrone Cesare C
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150211 5
During the past decades, candidate drugs that have shown neuroprotective efficacy in the preclinical setting have failed in clinical stroke trials. As a result, no treatment for stroke based on neuroprotection is available today. The activation of the glucagon-like peptide 1 receptor (GLP-1) for reducing stroke damage is a relatively novel concept that has shown neuroprotective effects in animal models. In addition, clinical studies are currently ongoing. Herein, we review this emerging research ...[more]
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