Ontology highlight
ABSTRACT:
SUBMITTER: Bauer M
PROVIDER: S-EPMC4420865 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Bauer Martin M Karch Rudolf R Zeitlinger Markus M Philippe Cécile C Römermann Kerstin K Stanek Johann J Maier-Salamon Alexandra A Wadsak Wolfgang W Jäger Walter W Hacker Marcus M Müller Markus M Langer Oliver O
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150211 5
As P-glycoprotein (Pgp) inhibition at the blood-brain barrier (BBB) after administration of a single dose of tariquidar is transient, we performed positron emission tomography (PET) scans with the Pgp substrate (R)-[(11)C]verapamil in five healthy volunteers during continuous intravenous tariquidar infusion. Total distribution volume (VT) of (R)-[(11)C]verapamil in whole-brain gray matter increased by 273 ± 78% relative to baseline scans without tariquidar, which was higher than previously repor ...[more]