Functional proteomics mapping of a human signaling pathway.
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ABSTRACT:
SUBMITTER: Colland F
PROVIDER: S-EPMC442148 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Publications
Functional proteomics mapping of a human signaling pathway.
Colland Frédéric F Jacq Xavier X Trouplin Virginie V Mougin Christelle C Groizeleau Caroline C Hamburger Alexandre A Meil Alain A Wojcik Jérôme J Legrain Pierre P Gauthier Jean-Michel JM
Genome research 20040701 7
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the interaction network, and cellular functional assays performed on newly identified proteins involved in a human signaling pathway. As a proof of principle, we studied the Smad signaling system, which is regulated by members of the transforming growth factor beta (TGFbeta) superfamily. We used two-hybrid screen ...[more]
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