Ontology highlight
ABSTRACT:
SUBMITTER: Tsoi LC
PROVIDER: S-EPMC4422106 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nature communications 20150505
Psoriasis is a chronic autoimmune disease with complex genetic architecture. Previous genome-wide association studies (GWAS) and a recent meta-analysis using Immunochip data have uncovered 36 susceptibility loci. Here, we extend our previous meta-analysis of European ancestry by refined genotype calling and imputation and by the addition of 5,033 cases and 5,707 controls. The combined analysis, consisting of over 15,000 cases and 27,000 controls, identifies five new psoriasis susceptibility loci ...[more]