Ontology highlight
ABSTRACT:
SUBMITTER: Nunes-Alves C
PROVIDER: S-EPMC4422591 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nunes-Alves Cláudio C Booty Matthew G MG Carpenter Stephen M SM Rothchild Alissa C AC Martin Constance J CJ Desjardins Danielle D Steblenko Katherine K Kløverpris Henrik N HN Madansein Rajhmun R Ramsuran Duran D Leslie Alasdair A Correia-Neves Margarida M Behar Samuel M SM
PLoS pathogens 20150506 5
The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance are incompletely understood. Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens to establish chronic infection is unknown. Here we show that anatomically distinct hu ...[more]