Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.

ABSTRACT: Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for the disorder may differ between the sexes or between multiply affected families compared to cases with no family history. Additionally, limited data support a genetic basis for variation in onset and severity, but specific loci have not been identified. We performed genome-wide association studies (GWAS) examining genetic influences on age at onset (AAO) and illness severity as well as specific risk by sex or family history status using up to 2762 cases and 3187 controls from the International Schizophrenia Consortium (ISC). Subjects with a family history of schizophrenia demonstrated a slightly lower average AAO that was not significant following multiple testing correction (p=.048), but no diff

SUBMITTER: Bergen SE 

PROVIDER: S-EPMC4422643 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature