Unknown

Dataset Information

0

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.


ABSTRACT: Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.

SUBMITTER: Saigusa T 

PROVIDER: S-EPMC4422974 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Saigusa Takamitsu T   Bell P Darwin PD  

Physiology (Bethesda, Md.) 20150501 3


Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future cli  ...[more]

Similar Datasets

| S-EPMC2837604 | biostudies-literature
| S-EPMC4089452 | biostudies-literature
| S-EPMC2843931 | biostudies-literature
| S-EPMC6716585 | biostudies-literature
| S-EPMC2390981 | biostudies-literature
| S-EPMC9478168 | biostudies-literature
| S-EPMC3937536 | biostudies-literature
| S-EPMC3791976 | biostudies-literature
| S-EPMC3416980 | biostudies-literature
2012-02-16 | E-GEOD-35831 | biostudies-arrayexpress