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Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry.


ABSTRACT: Analytical probes capable of mapping molecular composition at the nanoscale are of critical importance to materials research, biology and medicine. Mass spectral imaging makes it possible to visualize the spatial organization of multiple molecular components at a sample's surface. However, it is challenging for mass spectral imaging to map molecular composition in three dimensions (3D) with submicron resolution. Here we describe a mass spectral imaging method that exploits the high 3D localization of absorbed extreme ultraviolet laser light and its fundamentally distinct interaction with matter to determine molecular composition from a volume as small as 50 zl in a single laser shot. Molecular imaging with a lateral resolution of 75 nm and a depth resolution of 20 nm is demonstrated. These results open opportunities to visualize chemical composition and chemical changes in 3D at the nanoscale.

SUBMITTER: Kuznetsov I 

PROVIDER: S-EPMC4423227 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Three-dimensional nanoscale molecular imaging by extreme ultraviolet laser ablation mass spectrometry.

Kuznetsov Ilya I   Filevich Jorge J   Dong Feng F   Woolston Mark M   Chao Weilun W   Anderson Erik H EH   Bernstein Elliot R ER   Crick Dean C DC   Rocca Jorge J JJ   Menoni Carmen S CS  

Nature communications 20150423


Analytical probes capable of mapping molecular composition at the nanoscale are of critical importance to materials research, biology and medicine. Mass spectral imaging makes it possible to visualize the spatial organization of multiple molecular components at a sample's surface. However, it is challenging for mass spectral imaging to map molecular composition in three dimensions (3D) with submicron resolution. Here we describe a mass spectral imaging method that exploits the high 3D localizati  ...[more]

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