Ontology highlight
ABSTRACT:
SUBMITTER: Naville M
PROVIDER: S-EPMC4423230 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150424
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage. Here we test this concept experimentally using the human X chromosome. We describe a scoring method to identify evolutionary maintenance of linkage between conserved noncoding elements and neighbouring genes. Chromatin marks associated with enhancer function are strongly correlated with thi ...[more]