Ontology highlight
ABSTRACT:
SUBMITTER: Kitazawa T
PROVIDER: S-EPMC4423235 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Kitazawa Taro T Takechi Masaki M Hirasawa Tatsuya T Adachi Noritaka N Narboux-Nême Nicolas N Kume Hideaki H Maeda Kazuhiro K Hirai Tamami T Miyagawa-Tomita Sachiko S Kurihara Yukiko Y Hitomi Jiro J Levi Giovanni G Kuratani Shigeru S Kurihara Hiroki H
Nature communications 20150422
The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain unknown. Here we show that lower-to-upper jaw transformation induced by inactivation of the Endothelin1-Dlx5/6 cascade involving Goosecoid results in loss of the tympanic membrane ...[more]