Ontology highlight
ABSTRACT:
SUBMITTER: Yatime L
PROVIDER: S-EPMC4423239 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Yatime Laure L Maasch Christian C Hoehlig Kai K Klussmann Sven S Andersen Gregers R GR Vater Axel A
Nature communications 20150422
L-Oligonucleotide aptamers (Spiegelmers) consist of non-natural L-configured nucleotides and are of particular therapeutic interest due to their high resistance to plasma nucleases. The anaphylatoxin C5a, a potent inflammatory mediator generated during complement activation that has been implicated with organ damage, can be efficiently targeted by Spiegelmers. Here, we present the first crystallographic structures of an active Spiegelmer, NOX-D20, bound to its physiological targets, mouse C5a an ...[more]