Dataset Information

Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease.

ABSTRACT:

Background and aims

Inflammatory bowel diseases (IBD) are considered to be dysregulated, immune-mediated disorders; and immunosuppressive medications are the mainstay of their treatment. Clinically, we have often observed low serum immunoglobulin (Ig) levels in these patients. The aim of this study was to assess the frequency and risk factors of secondary humoral immunodeficiency in IBD patients.

Methods

We conducted a cross-sectional study of eligible IBD patients with Crohn's disease (CD), ulcerative colitis (UC), indeterminate colitis (IC) or restorative proctocolectomy with ileal pouch, who having serum Ig measured. Demographic and clinical variables were measured. Univariate and multivariate analyses were performed.

Results

A total of 324 patients was included, with a mean age of 38.8 years and 158 (48.8%) being male. Low IgG, IgG1, IgA, and IgM were found in 22.7%, 23.4%, 7.9%, and 10.9% of patients, respectively. The shared risk factors for a low IgG or IgM level were increasing age [odds ratio (OR)?=?1.13; 95% confidence interval (CI) 1.03-1.23 for low IgG level and OR?=?1.33; 95% CI 1.15-1.56 for low IgM level] and hypoalbuminemia (OR?=?1.83; 95% CI 1.01-3.33 for low IgG level and OR?=?3.17; 95% CI 1.23-8.15 for low IgM level). In addition, thioprine use was associated with low IgA level (OR?=?2.76; 95% CI 1.03-7.39). IBD disease duration was a risk factor for low IgG1 level (OR?=?1.40; 95% CI 1.12-1.76). The presence of concurrent primary sclerosing cholangitis (OR?=?0.064; 95% CI 0.007-0.60) and the use of biologics (OR?=?0.16; 95% CI 0.033-0.79) were associated with normal IgG1 level. IgG level was lower in CD patients than that in UC/IC and ileal pouch patients (P?=?0.042). IgG and IgA levels were elevated in patients with inflammatory conditions of the pouch (P?=?0.01; P?=?0.003, respectively).

Conclusions

Low Ig level appears to be common in IBD patients. Increasing age, disease duration and hypoalbuminemia appeared to be risk factors. The findings may provide rationale for targeted therapy to boost humoral immunity in selected patients with IBD.

SUBMITTER: Rai T

PROVIDER: S-EPMC4423463 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Publications

Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease.

Rai Tarun T Wu Xianrui X Shen Bo B

Gastroenterology report 20150130 2

<h4>Background and aims</h4>Inflammatory bowel diseases (IBD) are considered to be dysregulated, immune-mediated disorders; and immunosuppressive medications are the mainstay of their treatment. Clinically, we have often observed low serum immunoglobulin (Ig) levels in these patients. The aim of this study was to assess the frequency and risk factors of secondary humoral immunodeficiency in IBD patients.<h4>Methods</h4>We conducted a cross-sectional study of eligible IBD patients with Crohn's di ...[more]

PMID: 25638221

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Project description:Background:Inflammatory bowel disease (IBD), is a debilitating group of chronic diseases including Crohn's Disease (CD) and ulcerative colitis (UC), which causes inflammation of the gut and affects millions of people worldwide. At different taxonomic levels, the structure of the gut microbiota is significantly altered in IBD patients compared to that of healthy individuals. However, it is unclear how these IBD-affected bacterial groups are related to other common bacteria in the gut, and how they are connected across different disease conditions at the global scale. Results:In this study, using faecal samples from patients with IBD, we show through diversity analysis of the microbial community structure based on the 16S rRNA gene that the gut microbiome of IBD patients is less diverse compared to healthy individuals. Furthermore, we have identified which bacterial groups change in abundance in both CD and UC compared to healthy controls. A substantial imbalance was observed across four major bacterial phyla including Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria, which together constitute?>?98% of the gut microbiota. Next, we reconstructed a bacterial family co-abundance network based on the correlation of abundance profiles obtained from the public gut microbiome data of?>?22,000 samples of faecal and gut biopsies taken from both diseased and healthy individuals. The data was compiled using the EBI metagenomics database (Mitchell et al. in Nucleic Acids Res 46:D726-D735, 2018). By mapping IBD-altered bacterial families to the network, we show that the bacterial families which exhibit an increased abundance in IBD conditions are not well connected to other groups, implying that these families generally do not coexist together with common gut organisms. Whereas, the bacterial families whose abundance is reduced or did not change in IBD conditions compared to healthy conditions are very well connected to other bacterial groups, suggesting they are highly important groups of bacteria in the gut that can coexist with other bacteria across a range of conditions. Conclusions:IBD patients exhibited a less diverse gut microbiome compared to healthy individuals. Bacterial groups which changed in IBD patients were found to be groups which do not co-exist well with common commensal gut bacteria, whereas bacterial groups which did not change in patients with IBD were found to commonly co-exist with commensal gut microbiota. This gives a potential insight into the dynamics of the gut microbiota in patients with IBD.

Dataset Information

Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease.

Background and aims

Methods

Results

Conclusions

Publications

Frequency and risk factors of low immunoglobulin levels in patients with inflammatory bowel disease.

Similar Datasets

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