Ontology highlight
ABSTRACT:
SUBMITTER: Brindisi M
PROVIDER: S-EPMC4423475 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Brindisi Margherita M Brogi Simone S Relitti Nicola N Vallone Alessandra A Butini Stefania S Gemma Sandra S Novellino Ettore E Colotti Gianni G Angiulli Gabriella G Di Chiaro Francesco F Fiorillo Annarita A Ilari Andrea A Campiani Giuseppe G
Scientific reports 20150507
Leishmaniasis is a neglected vector-born disease caused by a protozoan of the genus Leishmania and affecting more than 1.300.000 people worldwide. The couple tryparedoxin/tryparedoxin peroxidase is essential for parasite survival in the host since it neutralizes the hydrogen peroxide produced by macrophages during the infection. Herein we report a study aimed at discovering the first class of compounds able to non-covalently inhibit tryparedoxin peroxidase. We have solved the high-resolution str ...[more]