Ontology highlight
ABSTRACT:
SUBMITTER: Ferradini N
PROVIDER: S-EPMC4423914 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Ferradini Nicoletta N Iannacone Rina R Capomaccio Stefano S Metelli Alessandra A Armentano Nadia N Semeraro Lucia L Cellini Francesco F Veronesi Fabio F Rosellini Daniele D
PloS one 20150507 5
Heat shock proteins (HSPs) are molecular chaperones involved in many cellular functions. It has been shown that mammalian cytosolic HSP70 binds antigenic peptides mediating the activation of the immune system, and that it plays a determining role in tumour immunogenicity. This suggests that HSP70 may be used for the production of conjugated vaccines. Human and plant HSPs share high sequence similarity and some important biological functions in vitro. In addition, plant HSPs have no endotoxic sid ...[more]