Ontology highlight
ABSTRACT:
SUBMITTER: Thomas KA
PROVIDER: S-EPMC4424065 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Thomas Kimberly A KA Valenzuela Nicole M NM Reed Elaine F EF
Trends in molecular medicine 20150320 5
The pathophysiology of antibody-mediated rejection (AMR) in solid organ transplants is multifaceted and predominantly caused by antibodies directed against polymorphic donor human leukocyte antigens (HLAs). Despite the clearly detrimental impact of HLA antibodies (HLA-Abs) on graft function and survival, the prevention, diagnosis, and treatment of AMR remain a challenge. The histological manifestations of AMR reflect the signatures of HLA-Ab-triggered injury, specifically endothelial changes, re ...[more]