Ontology highlight
ABSTRACT:
SUBMITTER: Kinkel SA
PROVIDER: S-EPMC4424268 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Kinkel Sarah A SA Galeev Roman R Flensburg Christoffer C Keniry Andrew A Breslin Kelsey K Gilan Omer O Lee Stanley S Liu Joy J Chen Kelan K Gearing Linden J LJ Moore Darcy L DL Alexander Warren S WS Dawson Mark M Majewski Ian J IJ Oshlack Alicia A Larsson Jonas J Blewitt Marnie E ME
Blood 20150202 12
Polycomb repressive complex 2 (PRC2) plays a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is targeted to specific genomic loci within HSPCs remains unknown. Here we use short hairpin RNA-mediated knockdown to survey the function of PRC2 accessory factors that were defined in embryonic stem cells (ESCs) by testing t ...[more]