Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell PK
PROVIDER: S-EPMC4424439 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Mitchell Patrick K PK Lipsitch Marc M Hanage William P WP
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20150601 1670
Pneumococcal conjugate vaccines target the limited subset of the more than 90 known serotypes of Streptococcus pneumoniae responsible for the greatest burden of pneumococcal disease and antibiotic resistance. Following the introduction of these vaccines, serotypes not targeted were able to expand and resistance became more common within these types. Here we use a stochastic dynamic model of pediatric pneumococcal carriage to evaluate potential influences on the emergence of new resistant lineage ...[more]