Unknown

Dataset Information

0

VEGFR-1 overexpression identifies a small subgroup of aggressive prostate cancers in patients treated by prostatectomy.


ABSTRACT: The VEGFR-1 is suggested to promote tumor progression. In the current study we analyzed prevalence and prognostic impact of the VEGFR-1 by immunohistochemistry on a tissue microarray containing more than 3000 prostate cancer specimens. Results were compared to tumor phenotype, ETS-related gene (ERG) status, and biochemical recurrence. Membranous VEGFR-1 expression was detectable in 32.6% of 2669 interpretable cancers and considered strong in 1.7%, moderate in 6.7% and weak in 24.2% of cases. Strong VEGFR-1 expression was associated with TMPRSS2:ERG fusion status as determined by fluorescence in situ hybridization (FISH) and immunohistochemistry (p < 0.0001 each). Elevated VEGFR-1 expression was linked to high Gleason grade and advanced pT stage in TMPRSS2:ERG negative cancers (p = 0.0008 and p = 0.001), while these associations were absent in TMPRSS2:ERG positive cancers. VEGFR-1 expression was also linked to phosphatase and tensin homolog (PTEN) deletions. A comparison with prostate specific antigen (PSA) recurrence revealed that the 1.7% of prostate cancers with the highest VEGFR-1 levels had a strikingly unfavorable prognosis. This could be seen in all cancers, in the subsets of TMPRSS2:ERG positive or negative, PTEN deleted or undeleted carcinomas (p < 0.0001 each). High level VEGFR-1 expression is infrequent in prostate cancer, but identifies a subgroup of aggressive cancers, which may be candidates for anti-VEGFR-1 targeted therapy.

SUBMITTER: Tsourlakis MC 

PROVIDER: S-EPMC4425098 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5344324 | biostudies-literature
| S-EPMC7071906 | biostudies-literature
| S-EPMC4494977 | biostudies-literature
| S-EPMC3255989 | biostudies-literature
| S-EPMC5584151 | biostudies-literature
| S-EPMC3325250 | biostudies-literature
| S-EPMC4153758 | biostudies-other
| S-EPMC11289481 | biostudies-literature
| S-EPMC8742774 | biostudies-literature
| S-EPMC5831163 | biostudies-literature