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Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

ABSTRACT: Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

SUBMITTER: McDonald-Hyman C

PROVIDER: S-EPMC4425354 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature

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Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

McDonald-Hyman Cameron C Turka Laurence A LA Blazar Bruce R BR

Science translational medicine 20150301 280

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome. ...[more]

PMID: 25810312

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