Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers.

ABSTRACT: A series of novel ether-linked dimers of demethylepipodophyllotoxin are topoisomerase II poisons that exhibit higher levels of double-stranded versus single-stranded DNA cleavage than their corresponding monomers. The dimers also have higher levels of tumor cell cytotoxicity than the monomers, lending support to the two-drug model for interaction of demethylepipodophyllotoxins with human topoisomerase IIα.

SUBMITTER: Dunlap N 

PROVIDER: S-EPMC4425371 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature