Effect of metformin on progression of head and neck cancers, occurrence of second primary cancers, and cause-specific survival.

ABSTRACT:

Background

This study aimed to investigate the effect of metformin on progression of head and neck cancers, occurrence of second primary cancers, and cause-specific survival.

Methods

This study analyzed a retrospective cohort of 1,151 consecutive patients with head and neck squamous cell carcinoma who were treated at our hospital. Patients were divided into three groups: nondiabetic, nonmetformin, and metformin. Clinical characteristics, recurrence of index head and neck cancer, occurrence of second primary cancer, and survival were compared among the different groups.

Results

Of 1,151 patients, 99 (8.6%) were included in the metformin group, 79 (6.8%) were in the nonmetformin group, and 973 (84.5%) were in the nondiabetic group. Diabetic status and metformin exposure

SUBMITTER: Kwon M 

PROVIDER: S-EPMC4425387 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature