Molecular signatures of major depression.
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ABSTRACT:
SUBMITTER: Cai N
PROVIDER: S-EPMC4425463 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Molecular signatures of major depression.
Cai Na N Chang Simon S Li Yihan Y Li Qibin Q Hu Jingchu J Liang Jieqin J Song Li L Kretzschmar Warren W Gan Xiangchao X Nicod Jerome J Rivera Margarita M Deng Hong H Du Bo B Li Keqing K Sang Wenhu W Gao Jingfang J Gao Shugui S Ha Baowei B Ho Hung-Yao HY Hu Chunmei C Hu Jian J Hu Zhenfei Z Huang Guoping G Jiang Guoqing G Jiang Tao T Jin Wei W Li Gongying G Li Kan K Li Yi Y Li Yingrui Y Li Youhui Y Lin Yu-Ting YT Liu Lanfen L Liu Tiebang T Liu Ying Y Liu Yuan Y Lu Yao Y Lv Luxian L Meng Huaqing H Qian Puyi P Sang Hong H Shen Jianhua J Shi Jianguo J Sun Jing J Tao Ming M Wang Gang G Wang Guangbiao G Wang Jian J Wang Linmao L Wang Xueyi X Wang Xumei X Yang Huanming H Yang Lijun L Yin Ye Y Zhang Jinbei J Zhang Kerang K Sun Ning N Zhang Wei W Zhang Xiuqing X Zhang Zhen Z Zhong Hui H Breen Gerome G Wang Jun J Marchini Jonathan J Chen Yiping Y Xu Qi Q Xu Xun X Mott Richard R Huang Guo-Jen GJ Kendler Kenneth K Flint Jonathan J
Current biology : CB 20150423 9
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] = 1.29-1.37]) and telomere length (p = ...[more]
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