Ontology highlight
ABSTRACT:
SUBMITTER: Basak A
PROVIDER: S-EPMC4425566 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Basak Anindita A Query Charles C CC
Cell reports 20140807 4
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), they are not known to have physiologic roles in cell differentiation. We have identified a pseudouridine residue (Ψ28) on spliceosomal U6 snRNA that is induced during filamentous growth of Saccharomyces cerevisiae. Pus1p catalyzes this modification and is upregulated during filamentation. Several U6 snRNA mutants are strongly pseudouridylated at Ψ28. Remarkably, these U6 mutants activate pseudohypha ...[more]