Ontology highlight
ABSTRACT:
SUBMITTER: Kumarasamy N
PROVIDER: S-EPMC4425828 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kumarasamy Nagalingeswaran N Aga Evgenia E Ribaudo Heather J HJ Wallis Carole L CL Katzenstein David A DA Stevens Wendy S WS Norton Michael R MR Klingman Karin L KL Hosseinipour Mina C MC Crump John A JA Supparatpinyo Khuanchai K Badal-Faesen Sharlaa S Bartlett John A JA
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20150218 10
<h4>Background</h4>The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir (LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency virus (HIV) regimens in Africa and Asia.<h4>Methods</h4>Eligible subjects had received first-line regimens for at least 6 months and had plasma HIV-1 RNA levels 1000-200 000 copies/mL. All subjects received LPV/r 400/100 mg twice daily. VF was defined as failure to suppress to <400 copies/mL by week 24, or con ...[more]