An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated BCL6 expression.
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ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC4426003 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.
Zhang Baochun B Calado Dinis Pedro DP Wang Zhe Z Fröhler Sebastian S Köchert Karl K Qian Yu Y Koralov Sergei B SB Schmidt-Supprian Marc M Sasaki Yoshiteru Y Unitt Christine C Rodig Scott S Chen Wei W Dalla-Favera Riccardo R Alt Frederick W FW Pasqualucci Laura L Rajewsky Klaus K
Cell reports 20150423 5
Diffuse large B cell lymphoma (DLBCL) is a complex disease comprising diverse subtypes and genetic profiles. Possibly because of the prevalence of genetic alterations activating canonical NF-κB activity, a role for oncogenic lesions that activate the alternative NF-κB pathway in DLBCL has remained elusive. Here, we show that deletion/mutation of TRAF3, a negative regulator of the alternative NF-κB pathway, occurs in ∼15% of DLBCLs and that it often coexists with BCL6 translocation, which prevent ...[more]
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