Ontology highlight
ABSTRACT:
SUBMITTER: Pehlivan D
PROVIDER: S-EPMC4426057 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Pehlivan Davut D Coban Akdemir Zeynep Z Karaca Ender E Bayram Yavuz Y Jhangiani Shalini S Yildiz Edibe Pembegul EP Muzny Donna D Uluc Kayihan K Gibbs Richard A RA Elcioglu Nursel N Lupski James R JR Harel Tamar T
Human genetics 20150417 6
Charcot-Marie-Tooth disease is a heterogeneous group of inherited distal symmetric polyneuropathies associated with mutations in genes encoding components essential for normal functioning of the Schwann cell and axon. TRIM2, encoding a ligase that ubiquitinates the neurofilament light chain, was recently associated with early-onset neuropathy in a single patient. We report a TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord p ...[more]