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Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis.


ABSTRACT: Charcot-Marie-Tooth disease is a heterogeneous group of inherited distal symmetric polyneuropathies associated with mutations in genes encoding components essential for normal functioning of the Schwann cell and axon. TRIM2, encoding a ligase that ubiquitinates the neurofilament light chain, was recently associated with early-onset neuropathy in a single patient. We report a TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord paralysis, allowing for further delineation of the associated phenotypic spectrum.

SUBMITTER: Pehlivan D 

PROVIDER: S-EPMC4426057 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Exome sequencing reveals homozygous TRIM2 mutation in a patient with early onset CMT and bilateral vocal cord paralysis.

Pehlivan Davut D   Coban Akdemir Zeynep Z   Karaca Ender E   Bayram Yavuz Y   Jhangiani Shalini S   Yildiz Edibe Pembegul EP   Muzny Donna D   Uluc Kayihan K   Gibbs Richard A RA   Elcioglu Nursel N   Lupski James R JR   Harel Tamar T  

Human genetics 20150417 6


Charcot-Marie-Tooth disease is a heterogeneous group of inherited distal symmetric polyneuropathies associated with mutations in genes encoding components essential for normal functioning of the Schwann cell and axon. TRIM2, encoding a ligase that ubiquitinates the neurofilament light chain, was recently associated with early-onset neuropathy in a single patient. We report a TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord p  ...[more]

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