Ontology highlight
ABSTRACT:
SUBMITTER: Jain S
PROVIDER: S-EPMC4426255 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Jain Surbhi S Xie Lijia L Boldbaatar Batbold B Lin Selena Y SY Hamilton James P JP Meltzer Stephen J SJ Chen Shun-Hua SH Hu Chi-Tan CT Block Timothy M TM Song Wei W Su Ying-Hsiu YH
Hepatology research : the official journal of the Japan Society of Hepatology 20141209 11
<h4>Aim</h4>Aberrant methylation of the promoter, P2, and the first exon, E1, regions of the tumor suppressor gene RASSF1A, have been associated with hepatocellular carcinoma (HCC), albeit with poor specificity. This study analyzed the methylation profiles of P1, P2 and E1 regions of the gene to identify the region of which methylation most specifically corresponds to HCC and to evaluate the potential of this methylated region as a biomarker in urine for HCC screening.<h4>Methods</h4>Bisulfite D ...[more]