Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez A
PROVIDER: S-EPMC4426574 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
González Andrea A Valck Carolina C Sánchez Gittith G Härtel Steffen S Mansilla Jorge J Ramírez Galia G Fernández María Soledad MS Arias José Luis JL Galanti Norbel N Ferreira Arturo A
The American journal of tropical medicine and hygiene 20150309 5
Trypanosoma cruzi calreticulin (TcCRT), a 47-kDa chaperone, translocates from the endoplasmic reticulum to the area of flagellum emergence. There, it binds to complement components C1 and mannan-binding lectin (MBL), thus acting as a main virulence factor, and inhibits the classical and lectin pathways. The localization and functions of TcCRT, once the parasite is inside the host cell, are unknown. In parasites infecting murine macrophages, polyclonal anti-TcCRT antibodies detected TcCRT mainly ...[more]