Ontology highlight
ABSTRACT:
SUBMITTER: Bennett JL
PROVIDER: S-EPMC4426682 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Bennett Jeffrey L JL O'Connor Kevin C KC Bar-Or Amit A Zamvil Scott S SS Hemmer Bernhard B Tedder Thomas F TF von Büdingen H-Christian HC Stuve Olaf O Yeaman Michael R MR Smith Terry J TJ Stadelmann Christine C
Neurology(R) neuroimmunology & neuroinflammation 20150507 3
Neuromyelitis optica (NMO) is an inflammatory autoimmune disorder of the CNS that predominantly affects the spinal cord and optic nerves. A majority (approximately 75%) of patients with NMO are seropositive for autoantibodies against the astrocyte water channel aquaporin-4 (AQP4). These autoantibodies are predominantly IgG1, and considerable evidence supports their pathogenicity, presumably by binding to AQP4 on CNS astrocytes, resulting in astrocyte injury and inflammation. Convergent clinical ...[more]