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Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.

ABSTRACT: Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced fractional anisotropy in the corpus callosum with no overt pathological features. Herein we show that moderate hypertension alone or with additional risk factors has minimal impact on white matter integrity in this model.

SUBMITTER: Holland PR 

PROVIDER: S-EPMC4426747 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.

Holland Philip R PR   Pannozzo Mercede A MA   Bastin Mark E ME   McNeilly Allison D AD   Ferguson Karen J KJ   Caughey Sarah S   Jansen Maurits A MA   Merrifield Gavin D GD   Marshall Ian I   Mullins John J JJ   Wardlaw Joanna M JM   Sutherland Calum C   Horsburgh Karen K  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20141119 2

Hypertension is linked with an increased risk of white matter hyperintensities; however, recent findings have questioned this association. We examined whether hypertension and additional cerebrovascular risk factors impacted on white matter integrity in an inducible hypertensive rat. No white matter hyperintensities were observed on magnetic resonance imaging either alone or in conjunction with ageing and high-fat diet. Aged hypertensive rats that were fed a high-fat diet had moderately reduced  ...[more]

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