Ontology highlight
ABSTRACT:
SUBMITTER: Ji J
PROVIDER: S-EPMC4426750 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Ji Jing J Baart Sophie S Vikulina Anna S AS Clark Robert Sb RS Anthonymuthu Tamil S TS Tyurin Vladimir A VA Du Lina L St Croix Claudette M CM Tyurina Yulia Y YY Lewis Jesse J Skoda Erin M EM Kline Anthony E AE Kochanek Patrick M PM Wipf Peter P Kagan Valerian E VE Bayır Hülya H
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20141119 2
It is believed that biosynthesis of lipid mediators in the central nervous system after cerebral ischemia-reperfusion starts with phospholipid hydrolysis by calcium-dependent phospholipases and is followed by oxygenation of released fatty acids (FAs). Here, we report an alternative pathway whereby cereberal ischemia-reperfusion triggered oxygenation of a mitochondria-specific phospholipid, cardiolipin (CL), is followed by its hydrolysis to yield monolyso-CLs and oxygenated derivatives of fatty ( ...[more]