Ontology highlight
ABSTRACT:
SUBMITTER: Jacobson BA
PROVIDER: S-EPMC4426951 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Jacobson Blake A BA Chen Esther Z EZ Tang Shaogeng S Belgum Holly Sedgwick HS McCauley Joel A JA Evenson Kristen A KA Etchison Ryan G RG Jay-Dixon Joe J Patel Manish R MR Raza Ahmad A Saluja Ashok K AK D'Cunha Jonathan J Kratzke Robert A RA
Genes & cancer 20150301 3-4
Malignant mesothelioma is a devastating disease with a poor prognosis for which there is a clear need for more successful therapeutic approaches. Triptolide, a diterpenoid triepoxide, is a highly effective agent against several cancer types in animal models. Owing to triptolide's poor solubility in water, a water-soluble analog, minnelide, was synthesized. Minnelide is a prodrug of triptolide and is activated by exposure to phosphatases that are found in all body tissues, including blood. Mesoth ...[more]