Ontology highlight
ABSTRACT:
SUBMITTER: Phan IQ
PROVIDER: S-EPMC4427173 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20150507 Pt 5
Prior studies have highlighted the potential of superoxide dismutases as drug targets in eukaryotic pathogens. This report presents the structures of three iron-dependent superoxide dismutases (FeSODs) from Trypanosoma cruzi, Leishmania major and Babesia bovis. Comparison with existing structures from Plasmodium and other trypanosome isoforms shows a very conserved overall fold with subtle differences. In particular, structural data suggest that B. bovis FeSOD may display similar resistance to p ...[more]