Ontology highlight
ABSTRACT:
SUBMITTER: Thomas LR
PROVIDER: S-EPMC4427524 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Molecular cell 20150326 3
MYC is an oncoprotein transcription factor that is overexpressed in the majority of malignancies. The oncogenic potential of MYC stems from its ability to bind regulatory sequences in thousands of target genes, which depends on interaction of MYC with its obligate partner, MAX. Here, we show that broad association of MYC with chromatin also depends on interaction with the WD40-repeat protein WDR5. MYC binds WDR5 via an evolutionarily conserved "MYC box IIIb" motif that engages a shallow, hydroph ...[more]