Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC4427561 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Fu Ye Y Luo Guan-Zheng GZ Chen Kai K Deng Xin X Yu Miao M Han Dali D Hao Ziyang Z Liu Jianzhao J Lu Xingyu X Dore Louis C LC Weng Xiaocheng X Ji Quanjiang Q Mets Laurens L He Chuan C
Cell 20150430 4
N(6)-methyldeoxyadenosine (6mA or m(6)A) is a DNA modification preserved in prokaryotes to eukaryotes. It is widespread in bacteria and functions in DNA mismatch repair, chromosome segregation, and virulence regulation. In contrast, the distribution and function of 6mA in eukaryotes have been unclear. Here, we present a comprehensive analysis of the 6mA landscape in the genome of Chlamydomonas using new sequencing approaches. We identified the 6mA modification in 84% of genes in Chlamydomonas. W ...[more]