CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.
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ABSTRACT:
SUBMITTER: Huang QQ
PROVIDER: S-EPMC4429912 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis.
Huang Qi-Quan QQ Perlman Harris H Birkett Robert R Doyle Renee R Fang Deyu D Haines G Kenneth GK Robinson William W Datta Syamal S Huang Zan Z Li Quan-Zhen QZ Phee Hyewon H Pope Richard M RM
Nature communications 20150512
Dendritic cells (DCs) are critical for immune homeostasis. To target DCs, we generated a mouse line with Flip deficiency in cells that express cre under the CD11c promoter (CD11c-Flip-KO). CD11c-Flip-KO mice spontaneously develop erosive, inflammatory arthritis, resembling rheumatoid arthritis, which is dramatically reduced when these mice are crossed with Rag(-/-) mice. The CD8α(+) DC subset is significantly reduced, along with alterations in NK cells and macrophages. Autoreactive CD4(+) T cell ...[more]
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