PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
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ABSTRACT:
SUBMITTER: Ning X
PROVIDER: S-EPMC4430476 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
Ning Xinghai X Seo Wonewoo W Lee Seungjun S Takemiya Kiyoko K Rafi Mohammad M Feng Xuli X Weiss Daiana D Wang Xiaojian X Williams Larry L Camp Vernon M VM Eugene Malveaux M Taylor W Robert WR Goodman Mark M Murthy Niren N
Angewandte Chemie (International ed. in English) 20141021 51
A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination ...[more]
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