Ontology highlight
ABSTRACT:
SUBMITTER: Gouyer V
PROVIDER: S-EPMC4431476 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Gouyer Valérie V Dubuquoy Laurent L Robbe-Masselot Catherine C Neut Christel C Singer Elisabeth E Plet Ségolène S Geboes Karel K Desreumaux Pierre P Gottrand Frédéric F Desseyn Jean-Luc JL
Scientific reports 20150514
A weakening of the gut mucous barrier permits an increase in the access of intestinal luminal contents to the epithelial cells, which will trigger the inflammatory response. In inflammatory bowel diseases, there is an inappropriate and ongoing activation of the immune system, possibly because the intestinal mucus is less protective against the endogenous microflora. General strategies aimed at improving the protection of the intestinal epithelium are still missing. We generated a transgenic mous ...[more]